The Rebel Faction

Misfile -
A comic with a great, and unique, premise. An secretarial angel, while high on dope, misplaces several crucial files. In doing so, he wipes two years of a young woman's life away, specifically the two she spent getting into Harvard, and another young man is now... well.. a girl. Very funny comic and the artist is great. In fact, I've bought artwork from him. updates Mon-Wed-Fri

Girly
If your sensitive and uptight, don't check out this comic. The main characters are lesbians and some of the comedy can offend anyone with their hair screwed on too tight. Other than that, it's hilarious and highly recommended. updates Mon-Wed-Fri

The Mows -
KITTIES! A comic all about cats. Based on real cats. Very funny and cute. Updates daily.

Sluggy Freelance
Internet comic legend. If you haven't heard of it, check it out. Updates daily.

Megatokyo
Completely nerdish, with a hint of otaku fanboyism. Do not even click if you're still under the impression that even though you post on a Star Wars forum, you're still a total badass.

Ctrl+Alt+Del
A lot like PvP and Penny Arcade. A web comic completely for gamers. Many funny moments, Ethan is the man, and Zeke is even better.

Penny Arcade
This is the fucking legend baby. If you're into web comics, or you're into video games, and you do not have this in your favorites list, you should shut down your computer right now.

Heroes of WoW
A pretty new, seldomly updated, webcomic based in the World of Warcraft universe. Most of it is inside jokes that you need to have the game to get, but some is universal, and all of it is funny.

Applegeeks
Ren would joygasm if he read any of these. Fortunately, I know chances of him actually being around to read this thread are slim to none, so I won't have to bear the digust of giving him the sick pleasure. Still, some funny shit. Makes me want a Mac.

The Last Days of Foxhound
If you're a fan of the Metal Gear series, you'll totally dig this web comic. If you're not, don't bother. Its all inside jokes, and the art is really shitty, but if you have played the games its fucking hilarious.

8-bit Theater
I haven't been to this one in like a half a year, so I'm way behind. Hell, I wasn't even close to being up to date when I last read it. This is one of those comics where someone with absolutely no talent photoshopped around the graphics from some famous video game (in this case, the original Final Fantasy), and called it art. Fortunately, this guy is actually funny, so it makes up for the lack of originality.

The Perry Bible Fellowship
Some of its sick. Some of its weird. All of it is funny. One of the best comic series I've ever had the pleasure of reading. Requires no knowledge of anything to get it, and you will get it.

Errant Story
When it comes to internet legends, the inside man that all the other legendary comics talk about is Poe. His Expliotation Now was one of the first to blow the lid off comics using some amazing artistic skills. Even though he's stopped that comic, it still gets more traffic in it's archives than many others. Errant Story is his new comic and it's a far more intricate story, but still amazingly drawn. Funny too. Meji is an apprentice wizard taking her exams and she's decided the best way to pass them is to perform the ultimate spell, so no one can deny she's great. She just ignores the fact that the ultimate spell just kinda destroys the world too.

Angels2200
If you have a problem with lesbians, don't click. If not, go ahead because you'll find a well drawn space opera that has alot of Star Wars similarities. ((The creator is actually an independant film maker from new Zealand whose had small films in award shows, quite a few Star Wars parodies too)) It's 2200 and a virus has wiped out almost 95% of the male population. Since it's right in the middle of a war as well, everyone has had to do some major recruiting among the female population to find enough star pilots to continue their war.

Chugworth Academy
Very funny raunchy comic. The artist has some great coloring skills and a wicked sense of humor. Lots of fan service. Again, avoid if your offendable.

Striptease
Nice little pencil drawn comic that has a cast of interesting characters. Quirky modern storylines that are at times sad as well as funny. It takes awhile to get to be able to recognize everyone, however. LARGE cast.

Twelve Dragons
One of the best comics I've come across. Updates sporadicly however. Amazing artwork, immense interesting storylines, and great characters. Come visit Pangea and see what Grog and friends are doing to save the world.

Gucomics
A gamers comic that likes to poke fun at all things involving games.

Flintlocke's Guide to Azeroth
A down right funny comic based in WoW and made with actual sceenshots from the game.