Woahh you left out a few important ones. I'm stoked for these even though I never really played one of them much and the other I haven't played at all, but I know they are both huge classics..
Starcraft 2 and Diablo 3.
I'm also curious to see how Mirror's Edge turns out.
I've been contemplating giving Mass Effect a try but I figure I still have Oblivion to get through, which is one of the greatest RPGs of all time, so I don't need another hindering my progress in that. I've had Oblivion for over a year and still haven't spent enough time with it to get through the campaign.
Also wanted to give Sins of a Solar Empire a shot. Whenever I read about that game I think about how much it seems like something all of TRF would be into and we could play together. I'm kind of surprised no one has really gotten into it or suggested it for everyone here to play as a group. I mean... come on... it's all about galactic conquest!
Some games I highly recommend (all PC titles):
Crysis (if your computer can handle it)
The Orange Box (the Half Life series is one of the best FPS out there, and Portal is amazing)
BioShock (great story, very creepy)