I am really enjoying this game. And I agree about the roaches. Those flittering wings, or the fire-ants shuffle or the damned scorpions....freak me the heck out when I have the lights turned out and the sound turned up.
I did not like the VATS targeting at first but I got used to it and it saved my bacon a few times.
I helped out the Vance character and solved the fire ant problem of another town. There is still a ton of stuff to explore on the map (I haven't even gone into DC yet as I am taking my time doing all these side missions to get cool gear). I am playing a do-gooder and someone hired some mercs to take my head for 1000 bottle caps.
I've been using a power station as an HQ to store misc junk (if I need to zip there, pickup some crap, and zip back to Megaton to sell it for quick cash) but every time I zip over there these mercs come out of hiding and try to jump me and killing them is where I get my better weapons and armor. Love the Rancor monster-thingy (Deathclaw?) that comes out and draws their attention away from me.
I've been carrying around a broken sniper rifle and shotgun in the hopes of being able to fix them at some point but so far I haven't been able too. Hoping higher repair numbers may do the trick.
I love the laser pistol that turns everything into nice, neat ash piles. I so dislike leaving rotting carcasses all over the place.
Haven't gotten any helpers yet but I do not think I am that far along. I've only been playing for about 23 hours, I believe.
If you liked Oblivion, you will definitely like this game. In fact, I liked this game more than Oblivion but that's because I felt Oblivion got a little too monotonous. Going through Oblivion gate after Oblivion gate got old for me but I have not finished that game and will still pick it up every now and then. But a Post Apocalyptic world is more my style.
I will admit to a certain curiosity if Fallout would have some "Mass Effect" action going on with the females and I came close to finding out in Big Town with a girl named 'Buttercup' who was sweet on my heroic stature. Unfortunately, in defending that town against an impending Super Mutant Attack, she died before I could kill all of them. Alas.